The Desert

From Homestar Runner Wiki

Secret Desert Headquarters is where The Cheat Commandos find themselves while searching for Blue Laser's Secret Desert Head Quarters in the short "Cheat Commandos...O's."

Gunhaver is sure that the secret entrance to Blue Laser's secret desert headquarters is in the secret desert somewhere, because he thinks he remembers hearing something about it on the news. Actually, Blue Laser's secret desert headquarters was moved, so they didn't find anything.

It also may hold "The Strong Bad's" buffalo-style ranch in an Easter egg at the end of the email "pizzaz."