The Homestar Runner Mysfit-steries

From Homestar Runner Wiki

"The Homestar Runner Mysfit-steries" is a Scooby Doo-like cartoon written by Youdbetterbelieveit Chimendez that represents Strong Bad's memory of when he, Strong Mad, Homestar Runner, and Marzipan were teenagers in the Strong Bad Email "highschool". Common plot threads apparently included debating the existence of "mysterious," as well as Strong Bad and Strong Mad's attempts to emancipate Homestar from his ridiculous stripéd pants. At Homestar's insistance, they played in a band "just to be safe." Each of the characters bears a striking resemblance to a Scooby Doo character: Strong Bad looks like Shaggy, Homestar looks like Fred, Strong Mad looks like Velma, and Marzipan looks like Daphne.

As Strong Bad states, he has an "extremely unphotographic" memory. With that in mind, it's unlikely that this account of the characters' pasts can be considered canon.