From Homestar Runner Wiki
Guitar Hero is a series of video games formerly developed by Harmonix that enables players to play along to well-known rock songs using a guitar-shaped controller. The CEO of Harmonix, Alex Rigopulos, contacted The Brothers Chaps and asked if they would be willing to include a Homestar Runner song as a bonus track on Guitar Hero II (see Georgia Tech - 26 Apr 2007). Following the success of Guitar Hero II, Harmonix developed Guitar Hero Encore: Rocks the 80s and once again used a Homestar Runner song as part of the game's set list. Many had hoped that another sequel in the series, Guitar Hero III: Legends of Rock, developed by Neversoft, would feature another song from the Homestar Runner body of work. Unfortunately, neither this game nor the Harmonix-developed Rock Band features a Homestar Runner song.
 Guitar Hero IITrogdor is an unlockable bonus track in Guitar Hero II. The description given for the song in the game's menu reads:
The Trogdor song from
the Strong Bad Email
'dragon' was actually an
afterthought that was
added at the last minute.
Mike was finishing up
the cartoon and Matt
screaming the chorus
while making eggs.
The loading screen for the song displays what is apparently advice on playing the song from Strong Bad:
"For squeadlies, mash on the trembalo. For meadlies, tone up on your chord surpassers. Oh, and I'm awesome."
This advice is based on Strong Bad's guitar terminology from guitar.
 Guitar Hero Encore: Rocks the 80s
Because, It's Midnite is featured as an "encore" song in Guitar Hero Encore: Rocks the 80s. The song is considered particularly difficult, because of the main guitar solo.The loading screen for the song reads:
While on tour,
Limozeen used to
sheets from the
hotels they stayed
at until the rashes
and animal rights
activists became a
 Guitar Hero III: Legends of Rock
In Limozeen Live! (practice), Larry Palaroncini is seen holding a Guitar Hero III controller from the Nintendo Wii version of the game. He says he can only play on medium difficulty, while a pop-up informs us he can't pass the first song on easy.